Two sample MR report
CPNE1_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | -0.2610146 | 0.1181635 | 0.0516543 |
| Weighted median | 12 | -0.0884218 | 0.0212794 | 0.0000325 |
| Inverse variance weighted | 12 | -0.0605775 | 0.0183397 | 0.0009563 |
| Simple mode | 12 | -0.0915008 | 0.0309883 | 0.0131445 |
| Weighted mode | 12 | -0.0915008 | 0.0276233 | 0.0069233 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 12.01066 | 10 | 0.2843436 |
| Inverse variance weighted | 15.53879 | 11 | 0.1591350 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.2027425 | 0.1182922 | 0.1173163 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002065 | 0 | TRUE | 0.1747221 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
